Stanford University · PharmacologyThe Ethanol Enzyme Lab
Daria Mochly-Rosen · Stanford, California
Research Focus
Daria Mochly-Rosen's lab at Stanford University focuses on understanding how certain enzymes in our bodies interact with ethanol, a common substance consumed by many. The research highlights the role of aldehyde dehydrogenases, which help detoxify harmful compounds from alcohol metabolism, and how genetic variations in these enzymes can increase the risk of health problems. By studying these enzymes, especially in different genetic backgrounds, the lab aims to uncover new insights into alcohol-related diseases and contribute to personalized medicine approaches for better health outcomes.
aldehyde dehydrogenasesethanol metabolismgenetic variationmitochondrial dysfunctiontoxicityprecision medicineinflammationcell death
Research Aims
3AIM 01Identify genetic variants of aldehyde metabolizing enzymes across different ancestry groups.
AIM 02Examine the effects of inactive enzyme variants on mitochondrial function due to ethanol exposure.
AIM 03Investigate the impact of chronic ethanol treatment in genetically modified mice.
Skills the Lab Values
PCRcell culturemouse modelsin vitro enzyme assaysgenotypingbioinformaticsWestern blottingimmuofluorescence microscopyethanol exposure studiesgenetic engineering techniques
Output against the department
Publications472top 11% of dept.53rd of 462
this lab
most publishedleast published
Citations33ktop 8% of dept.36th of 462
this lab
most citedleast cited
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