The University of Texas Health Science Center at San Antonio · PharmacologyInflammation Insight Lab
Yuguang Shi · San Antonio, Texas
Research Focus
Dr. Yuguang Shi's lab at the University of Texas Health Science Center focuses on understanding how obesity leads to chronic inflammation, which is linked to metabolic diseases like insulin resistance. They specifically investigate a protein called ALCAT1 and its role in activating inflammation in fat tissue when faced with dietary challenges. This research could reveal new ways to treat obesity and related metabolic conditions by targeting ALCAT1.
obesitychronic inflammationinsulin resistanceNLRP3ALCAT1metabolic disordersprion-like proteinscardiolipinoxidative stress
Research Aims
3AIM 01Investigate how ALCAT1 promotes NLRP3 activation through mitochondrial dysfunction.
AIM 02Elucidate the molecular mechanisms by which ALCAT1 acts as a prion-like protein in obesity.
AIM 03Assess the impact of ALCAT1 on cellular senescence and chronic inflammation in adipose tissue.
Skills the Lab Values
cell culturediabetes modelsin vivo studiesWestern blotimmunofluorescenceRNA extractionPCRprotein purificationflow cytometry
Output against the department
Publications102bottom 26% of dept.339th of 462
this lab
most publishedleast published
Citations6.4kbottom 46% of dept.251st of 462
this lab
most citedleast cited
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