Tufts University · BiochemistryHeldwein Lab
Ekaterina Heldwein · Medford, Massachusetts
Research Focus
Dr. Ekaterina Heldwein's lab at Tufts University studies how herpesviruses exit the nucleus of infected cells to spread and cause disease. The team focuses on understanding the molecular mechanisms of virus membrane budding and fusion, particularly looking at proteins involved in these processes. Their research has implications for developing better vaccines and treatments for viral infections, especially in vulnerable populations.
herpesvirusesnuclear egressglycoprotein Bimmune responsevaccine development
Research Aims
5AIM 01Investigate the mechanisms of nucleotide egress in herpesviruses
AIM 02Visualize nuclear egress in infected cells using high-resolution techniques
AIM 03Characterize host factors that affect viral membrane fusion
AIM 04Determine the structure of prefusion glycoprotein B from HCMV
AIM 05Isolate and study neutralizing antibodies against HCMV glycoprotein B
Skills the Lab Values
cryoelectron tomographyprotein purificationstructural biologycell cultureantibody characterization
Output against the department
Publications104bottom 26% of dept.297th of 402
this lab
most publishedleast published
Citations4.2kbottom 23% of dept.309th of 402
this lab
most citedleast cited
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