Harvard University · BiochemistryStruhl Lab
Kevin Struhl · Cambridge, Massachusetts
Research Focus
Dr. Kevin Struhl's lab at Harvard Medical School focuses on understanding how genes are expressed in eukaryotic organisms, linking these mechanisms to human diseases. The research primarily investigates the processes of mRNA production, stability, and how specific RNA sequences affect gene regulation. Through innovative experiments and techniques, the lab aims to uncover the fundamental roles of transcription and mRNA processing in genetics and biological function.
gene regulationmRNA stabilitytranscriptionpolyadenylationRNA decayeukaryotic geneticsyeast modelsfunctional genomicsmRNA processing
Research Aims
5AIM 01Investigate the molecular mechanisms of gene expression regulation in eukaryotes.
AIM 02Analyze the impact of polyadenylation on mRNA stability.
AIM 03Examine the role of RNA-binding proteins in transcript stability.
AIM 04Explore the relationship between transcriptional processes and mRNA decay.
AIM 05Study the generation and regulation of transcript isoforms on a transcriptome scale.
Skills the Lab Values
molecular geneticsRNA sequencingcell culturegenetic engineeringfunctional genomicsCRISPRWestern blotbioinformaticsmetabolically labeling RNA
Output against the department
Publications435top 11% of dept.44th of 402
this lab
most publishedleast published
Citations61ktop 3% of dept.14th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.