Old Dominion University · Biomedical EngineeringThe Senescence Lab
Yan Sanders · Norfolk, Virginia
Research Focus
Dr. Yan Sanders' lab focuses on understanding and addressing the effects of cellular aging in the lungs of patients with Cystic Fibrosis (CF). They explore how epigenetic factors contribute to lung cell senescence, which leads to inflammation and decreased lung function. The research aims to develop new therapeutic strategies by targeting specific proteins that influence gene expression in aged lung cells, ultimately improving treatment for CF patients.
Cystic Fibrosiscellular senescenceepigeneticsBrd4transcription factors
Research Aims
3AIM 01Investigate the role of Brd4 in regulating gene expression associated with cellular senescence in CF lung cells.
AIM 02Examine the interaction between Brd4 and transcription factor AP-1 in senescent cells.
AIM 03Evaluate the effectiveness of Brd4 inhibition in restoring lung function in CF animal models.
Skills the Lab Values
epigenetic assayscell cultureATAC-seqtranscriptional regulationanimal modelinggene expression analysismolecular cloningimmunohistochemistrybiostatisticsRNA sequencing
Output against the department
Publications60bottom 7% of dept.551st of 595
this lab
most publishedleast published
Citations3.5kbottom 28% of dept.430th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.