Stanford University · Microbiology & ImmunologyBlau Regeneration Lab
Helen M Blau · Stanford, California
Research Focus
Dr. Helen M. Blau's lab at Stanford University focuses on understanding how aging affects muscle stem cells (MuSCs), which are crucial for muscle repair and regeneration. With the aging population facing challenges like sarcopenia, the lab investigates the mechanisms behind the decline in MuSC function and aims to enhance muscle regeneration through innovative technologies. The research combines cutting-edge single-cell analysis and in vivo experiments to uncover new therapeutic strategies to improve muscle health in elderly individuals.
muscle stem cellssarcopeniaagingsingle-cell analysisregenerationThrombospondin-1CD47muscle healthpublic healththerapeutics
Research Aims
5AIM 01Investigate how CD47 signaling changes with aging
AIM 02Characterize post-transcriptional regulation of CD47 in MuSCs
AIM 03Study the impact of THBS1 secretion on aged MuSCs
AIM 04Explore ways to enhance the regenerative capacity of functional MuSCs
AIM 05Develop therapeutic approaches to boost muscle repair in the elderly.
Skills the Lab Values
single-cell mass cytometry (CyTOF)multi-plexed tissue imaging (CODEX)in vivo mouse modelscell cultureflow cytometryblocking antibody techniquesmolecular biology techniquesdata visualizationcellular signaling analysisimmunohistochemistry
Output against the department
Publications377top 10% of dept.50th of 486
this lab
most publishedleast published
Citations58ktop 3% of dept.13th of 486
this lab
most citedleast cited
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