University of Colorado Boulder · ChemistryNeurodegeneration Research Lab
Alexandra Whiteley · Boulder, Colorado
Research Focus
Dr. Alexandra Whiteley's lab at the University of Colorado focuses on understanding the molecular mechanisms behind a severe neurodegenerative disease called ALS-FTD. They study proteins involved in neuronal dysfunction, particularly how the UBQLN2 protein affects another protein named PEG10, which may play a critical role in the disease's progression. The research aims to reveal new potential targets for therapies to treat this condition.
ALSneurodegenerationUBQLN2PEG10neuron dysfunctionproteasomecellular modelsanimal models
Research Aims
3AIM 01Investigate the abundance and proteolytic activity of PEG10 in ALS and FTD patient tissues.
AIM 02Determine the mechanism through which PEG10 contributes to UBQLN2-mediated disease in cellular models.
AIM 03Elucidate the molecular rules of UBQLN2-PEG10 interactions to form a detailed model for protein selection.
Skills the Lab Values
cell cultureanimal modelsWestern blotRNA sequencingproteomic analysisin vitro assaysimmunohistochemistrymolecular cloningdata analysis with Python
Output against the department
Publications19bottom 3% of dept.209th of 216
this lab
most publishedleast published
Citations286bottom 2% of dept.211th of 216
this lab
most citedleast cited
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