University of Toledo · BiochemistrySchiefer Toxicology Lab
Isaac T Schiefer · Toledo, Ohio
Research Focus
Dr. Isaac T. Schiefer's lab at the University of Toledo focuses on understanding the effects and toxicity of synthetic psychoactive substances known as bath salts. The research aims to identify drug targets and develop novel therapeutic strategies to address substance abuse disorders and the associated health risks. The lab combines molecular biology techniques with behavioral studies to gain comprehensive insights into how these substances interact with the brain and body.
bath saltspsychoactive agentsdrug targetstoxicitybehavioral paradigmsphotoaffinity labelingproteomicssubstance abusesynthetic drugs
Research Aims
5AIM 01Synthesize probes for studying the binding profile of psychoactive substances.
AIM 02Assess the effects of substances on monoamine uptake and neuronal release.
AIM 03Investigate the toxicity of psychoactive agents in various cell lines.
AIM 04Conduct behavioral studies in adult zebrafish to correlate drug exposure with behavioral outcomes.
AIM 05Utilize chemical biology techniques to visualize protein interactions and identify novel drug targets.
Skills the Lab Values
photoaffinity labelingsynthesis of chemical probesliquid chromatography-mass spectrometry (LC-MS)zebrafish behavioral assaysaffinity purificationproteomicsbioinformaticscell cultureSDS-PAGE gel imaging
Output against the department
Publications53bottom 8% of dept.366th of 402
this lab
most publishedleast published
Citations765bottom 1% of dept.396th of 402
this lab
most citedleast cited
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