University of California-Irvine · Biomedical EngineeringTau Imaging Initiative
Jogeshwar Mukherjee · Irvine, California
Research Focus
Dr. Mukherjee's lab at UC Irvine focuses on developing innovative imaging agents to help diagnose and understand Alzheimer's disease. The primary goal is to create novel tracers that can bind to Tau proteins, which are critical in understanding the progression of this neurodegenerative disease. By utilizing advanced imaging techniques like PET and SPECT, the lab aims to improve early detection and treatment strategies for Alzheimer's and related disorders.
Alzheimer's diseaseTau proteinneuroimagingradiohalogenated agentsPETSPECTradioligandsneurofibrillary tanglesdementiabiomarkers
Research Aims
5AIM 01Design and develop novel radiohalogenated tracers that bind to Tau proteins.
AIM 02Evaluate the effectiveness of these tracers in postmortem human brains.
AIM 03Compare binding affinity and specificity of new tracers to existing imaging agents.
AIM 04Assess the metabolic stability and brain penetration of radiotracers in animal models.
AIM 05File an exploratory IND application with the FDA for a selected imaging agent.
Skills the Lab Values
radioactive imaging techniquesSPECTPETradiochemistryautoradiographyimmunohistochemistrymouse modelsdata analysisligand binding assaysexperimental design
Output against the department
Publications247top 40% of dept.237th of 595
this lab
most publishedleast published
Citations4.9kbottom 37% of dept.373rd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.