West Virginia University · BiochemistryThe Proteostasis Lab
David Matthew Smith · Morgantown, West Virginia
Research Focus
Dr. David Matthew Smith's lab at West Virginia University focuses on understanding the role of protein degradation in neurodegenerative diseases, particularly Alzheimer's Disease. The lab investigates how the failure of the proteasome system leads to the accumulation of toxic proteins in neurons. By studying unique pathways that bypass traditional protein degradation mechanisms, the lab aims to identify potential therapeutic strategies to enhance neuronal health and combat neurodegenerative disorders.
neurodegenerative diseasesAlzheimer's Diseaseproteasomeprotein degradationubiquitin-independent pathwaysCaenorhabditis elegansneuroprotectioncellular healththerapeutic strategies
Research Aims
5AIM 01Understand the mechanisms of IDP (intrinsically disordered protein) degradation in neurodegenerative diseases.
AIM 02Investigate the role of ubiquitin-independent pathways in protecting neurons from toxic protein accumulation.
AIM 03Develop therapeutic strategies to enhance proteasomal function and prevent neurodegeneration.
AIM 04Explore the impact of proteasome activation on organismal longevity and neuroprotection.
AIM 05Elucidate the specific pathways of protein degradation influenced by various proteasome complexes.
Skills the Lab Values
protein purificationanimal models (C. elegans)Western blotcryoelectron microscopyprotein assayscell culturegenetic modification techniquesdata analysis using Pythonbiochemical characterization