Yale University · NeuroscienceParkinson's Genetics and Dementia Lab
Clemens R Scherzer · New Haven, Connecticut
Research Focus
Dr. Clemens R. Scherzer's lab at Yale University focuses on understanding how genetic factors contribute to the progression of Parkinson's disease, particularly in relation to cognitive decline and dementia. The research aims to identify specific genetic markers that can predict the risk of developing dementia in Parkinson's patients, which could change how we approach treatment and management of the disease. By analyzing data from a large number of patients over time, the lab seeks to improve clinical outcomes for individuals affected by Parkinson's disease.
Parkinson's diseasedementiagenetic markerscognitive declineclinical prognostication
Research Aims
3AIM 01Discover novel genetic loci associated with progression to dementia in Parkinson's disease.
AIM 02Replicate and verify genetic variants in different patient populations.
AIM 03Develop a Polygenic Hazard Score to predict cognitive decline risks.
Skills the Lab Values
genome-wide association studieslongitudinal data analysisCox proportional hazards modelingmixed effects modelingbioinformatics
Output against the department
Publications191top 39% of dept.259th of 671
this lab
most publishedleast published
Citations11ktop 36% of dept.242nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.