University of Louisville · Microbiology & ImmunologyAlphavirus Innovation Lab
Donghoon Chung · Louisville, Kentucky
Research Focus
Dr. Donghoon Chung's research lab at the University of Louisville focuses on developing new antiviral therapies specifically targeting arthritogenic alphaviruses like Chikungunya. The lab aims to optimize a unique antiviral compound that has shown promise against certain alphaviruses and enhance its effectiveness against other forms of these viruses, which have the potential to cause significant public health challenges. The multidisciplinary team combines efforts in structural biology, medicinal chemistry, and virology to create next-generation antiviral drugs.
alphavirusesantiviralsChikungunya virusdrug discoverypandemic preparedness
Research Aims
3AIM 01Develop novel antiviral compounds for arthritogenic alphaviruses.
AIM 02Improve the potency of quinazoline-based antivirals against Old World alphaviruses.
AIM 03Investigate the molecular interactions of antiviral compounds with viral targets.
Skills the Lab Values
medicinal chemistrymolecular modelingin vitro assaysin vivo studiesstructural biologypharmacological profilingviral replication studieschemical synthesisbioinformatics
Output against the department
Publications56bottom 14% of dept.416th of 486
this lab
most publishedleast published
Citations966bottom 5% of dept.460th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.