Columbia University in the City of New York · Microbiology & ImmunologyDNA Repair Mechanisms Laboratory
Lorraine S Symington · New York, New York
Research Focus
Dr. Lorraine S. Symington's lab at Columbia University focuses on understanding how cells repair DNA damage, specifically double-strand breaks (DSBs). These breaks can lead to serious genetic issues if not properly repaired, contributing to diseases like cancer. Using the yeast Saccharomyces cerevisiae as a model organism, the lab investigates the molecular mechanisms of DSB repair and the factors that influence these processes, including the role of various proteins and chromatin structures. This research could have important implications for developing new cancer treatments and understanding genomic stability.
DNA double-strand breaksDNA repairhomologous recombinationyeast modelinggenomic instabilitychromatin remodelingcancer biologyreplication stresstherapeutic development
Research Aims
5AIM 01Investigate the mechanisms of DNA double-strand break repair using yeast as a model.
AIM 02Explore how chromatin remodeling factors influence end resection of DNA breaks.
AIM 03Utilize site-specific replication fork collapse to study DSB repair processes.
AIM 04Identify novel proteins involved in the repair of collapsed replication forks.
AIM 05Understand the link between DSB repair mechanisms and genomic instability related to cancer.
Skills the Lab Values
DNA sequencingchromatin remodeling techniquesyeast cell culturemolecular cloninggene editing with Cas9micrococcal nuclease digestiongenetic recombination analysiscell survival assaysS1-seqMNase-seq
Output against the department
Publications167top 40% of dept.192nd of 486
this lab
most publishedleast published
Citations15ktop 25% of dept.123rd of 486
this lab
most citedleast cited
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