Boston University · BiologyIshibashi Regenerative Lab
Nobuyuki Ishibashi · Boston, Massachusetts
Research Focus
Dr. Nobuyuki Ishibashi's lab at Boston University Medical Campus focuses on improving neurological outcomes for children with congenital heart disease (CHD) using innovative cell therapy approaches. The lab is investigating how bone marrow-derived mesenchymal stromal cells (BM-MSCs) can be delivered via cardiopulmonary bypass during cardiac surgeries to repair brain tissue and enhance recovery. Their research includes understanding the molecular mechanisms of these therapies and identifying bioactive molecules that could lead to new treatments.
cell therapycongenital heart diseaseneuroprotectionbone marrow-derived cellsexosomespediatric cardiac surgerytissue repairregenerative medicine
Research Aims
4AIM 01Investigate the therapeutic effects of BM-MSCs delivered during cardiac surgeries on neurological impairments.
AIM 02Identify molecular signatures of critical cell populations post-BM-MSC delivery.
AIM 03Explore the role of exosomal molecules in enhancing tissue repair and neuroprotection.
AIM 04Understand the mechanisms by which BM-MSCs promote recovery in neurological function after surgery.
Skills the Lab Values
cell culturefluorescence microscopymolecular profilingRNA extractionbioinformaticsanimal modelstranscriptomic analysisexosome isolationbiostatistics
Output against the department
Publications55bottom 13% of dept.893rd of 1,033
this lab
most publishedleast published
Citations3.3kbottom 25% of dept.774th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.