University of California-San Francisco · NeuroscienceCanzio Lab
Daniele Canzio · San Francisco, California
Research Focus
Dr. Daniele Canzio's lab at UCSF focuses on understanding how the genome's structure affects brain development and function. By studying specific cell-surface proteins, the lab investigates how neurons recognize and avoid self-damage during their growth and wiring. This research not only sheds light on normal brain development but is also key to understanding disorders related to neural connectivity.
neural developmentgenome architecturecohesinProtocadherinneural self-avoidancemolecular biologyneurodevelopmental disordersgene expressionmouse modelsneurology
Research Aims
5AIM 01Investigate how individual neurons express different combinations of Protocadherin genes.
AIM 02Explore the role of cohesin in regulating gene expression during brain development.
AIM 03Understand the mechanisms of neural self-avoidance in developing neurons.
AIM 04Examine the relationship between genome architecture and neuronal function.
AIM 05Link molecular operations of cohesin to neural circuit assembly.
Skills the Lab Values
cell culturegenome editingRNA sequencingmouse modelsimmunohistochemistryWestern blotbioinformaticsfluorescence microscopy
Output against the department
Publications28bottom 5% of dept.638th of 671
this lab
most publishedleast published
Citations2.8kbottom 19% of dept.545th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.