University of Southern California · PhysiologyMacula Densa Cell Research Lab
Janos Peti-Peterdi · Los Angeles, California
Research Focus
Dr. Janos Peti-Peterdi's research lab at the University of Southern California focuses on understanding the roles of specific kidney cells known as macula densa cells. These cells contribute to kidney health and disease, particularly in chronic kidney disease (CKD). The lab employs advanced imaging techniques and experimental models to investigate how these cells communicate with glomerular endothelial cells and regulate kidney functions, which could lead to new therapeutic strategies for kidney diseases.
kidney diseaseglomerular endothelial cellsmacula densachronic kidney diseasecell signalingneuron-like functionsangiogenesisintravitreal imaginggene therapy
Research Aims
3AIM 01Examine the functional importance of macula densa cell factors in maintaining glomerular endothelial health.
AIM 02Investigate how alterations in macula densa function contribute to chronic kidney disease progression.
AIM 03Explore therapeutic targets from the neuron-like signaling of macula densa cells for kidney disease treatment.
Skills the Lab Values
cell culture techniquesmultiphoton microscopytransgenic mouse modelsin vivo imaginggene delivery methodscalcium signaling analysishistologyRNA sequencingoptogenetics
Output against the department
Publications302top 16% of dept.46th of 286
this lab
most publishedleast published
Citations9.5ktop 35% of dept.101st of 286
this lab
most citedleast cited
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