University of Texas Southwestern Medical Center · Microbiology & ImmunologyCircadian Immunity Research Group
John David Farrar · Dallas, Texas
Research Focus
Dr. John David Farrar's lab at UT Southwestern Medical Center studies how the body's internal clocks, known as circadian rhythms, affect immune responses, particularly in T cells responding to influenza. The lab investigates the role of specific receptors that communicate signals from the nervous system to immune cells, aiming to better understand how timing influences the effectiveness of immunity. This research could lead to advancements in vaccine design and improve our insights into how time-related factors such as jet lag affect immune function during viral infections.
circadian rhythmsCD8 T cellsinfluenzaimmune responseadrenergic signaling
Research Aims
3AIM 01Investigate the role of ADRB2 in regulating CD8+ T cell responses to influenza.
AIM 02Examine how circadian rhythm genes affect T cell immunity during infection.
AIM 03Evaluate the impact of jet lag on immune responses to influenza.
Skills the Lab Values
cell culturemouse modelsPCRgene expression analysisflow cytometryimmunohistochemistry
Output against the department
Publications2bottom 2% of dept.477th of 486
this lab
most publishedleast published
Citations0bottom 1% of dept.481st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.