University of California-Irvine · PhysiologyUbiquitin-Proteasome Research Laboratory
Lan Huang · Irvine, California
Research Focus
Dr. Lan Huang's lab focuses on understanding how proteins interact within cells, specifically looking at a system known as the ubiquitin-proteasome system that helps manage protein degradation. By advancing new technologies in mass spectrometry, the lab aims to unravel the complex networks of these protein interactions to shed light on their roles in diseases such as cancer and neurodegenerative disorders. This research could lead to new therapies that target these vital biological processes.
ubiquitin-proteasome systemprotein-protein interactionsmass spectrometryproteomicsdisease mechanisms
Research Aims
5AIM 01Develop novel mass spectrometry technologies to analyze protein interactions
AIM 02Map the ubiquitin-proteasome system to reveal its molecular dynamics
AIM 03Investigate the role of Cullin-RING Ligases in protein ubiquitination
AIM 04Examine the action mechanisms of proteasome regulators in protein degradation
AIM 05Advance our understanding of how protein networks relate to human diseases.
Skills the Lab Values
cross-linking mass spectrometryprotein interaction mappingcell culturestructural biology techniquesdata analysis with Python
Output against the department
Publications334top 13% of dept.37th of 286
this lab
most publishedleast published
Citations16ktop 20% of dept.57th of 286
this lab
most citedleast cited
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