University of Texas Southwestern Medical Center · NeuroscienceHuber Lab
Kimberly M. Huber · Dallas, Texas
Research Focus
Dr. Kimberly M. Huber's lab investigates how Autism Spectrum Disorder (ASD) affects males and females differently, particularly through the lens of brain circuitry. By using mouse models, the lab explores the role of certain genes, like Pten, in creating sex-specific brain function and sensory processing challenges. Their research aims to illuminate how these differences may impact behavior and brain connectivity, providing insights that could inform future treatments for ASD.
Autism Spectrum Disordersex differencesbrain circuitryPten genemetabotropic glutamate receptors
Research Aims
4AIM 01Determine the sex-specific effects of mGluR5 on neuron properties in Pten deficient mice.
AIM 02Investigate the ribosome-linked transcript changes regulated by PTEN in female cortical neurons.
AIM 03Assess if mGluR5 or ER function reduction alleviates sensory processing deficits in females.
AIM 04Examine the impact of estrogen and estrus cycles on cortical circuit dysfunction related to ASD.
Skills the Lab Values
mouse modelselectrophysiologyimmunohistochemistrybehavioral assaysRNA sequencing
Output against the department
Publications124bottom 44% of dept.377th of 671
this lab
most publishedleast published
Citations14ktop 29% of dept.195th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.