University of Chicago · GeneticsMechanobiology Research Laboratory
Margaret Lise Gardel · Chicago, Illinois
Research Focus
Dr. Margaret Lise Gardel's research lab focuses on how cells interact with mechanical signals to influence their behavior, such as growth and movement. Through a combination of techniques, including live imaging and mathematical modeling, the lab investigates how the structures within cells, particularly the cytoskeleton, respond to forces. This work is significant for understanding not only basic biology but also potential treatments for diseases like cancer and heart conditions.
cell mechanicsmechanobiologycytoskeletonforce-sensingcell adhesionbiophysicslive cell imagingmechanotransductionLIM domain proteinstissue engineering
Research Aims
5AIM 01Investigate how cells process mechanical signals to control their behavior.
AIM 02Understand the role of the cytoskeleton in cell mechanics and its influence on cell division.
AIM 03Explore the mechanisms of mechanosensing through LIM domain proteins.
AIM 04Develop new experimental tools for probing biological systems at the cellular level.
AIM 05Advance the field of cellular biophysics and its applications in health and disease.
Skills the Lab Values
PCRcell culturelive cell imagingmathematical modelingoptogeneticsimmunofluorescencemechanobiology assaysforce-sensing analysisdata-driven modelingbiophysical measurement techniques
Output against the department
Publications258top 31% of dept.80th of 259
this lab
most publishedleast published
Citations15ktop 38% of dept.99th of 259
this lab
most citedleast cited
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