Yale University · Microbiology & ImmunologyHepatic Harmony Lab
Richard A Flavell · New Haven, Connecticut
Research Focus
Dr. Richard Flavell's lab at Yale University focuses on studying Alcoholic Liver Disease (ALD), particularly Alcohol Associated Hepatitis (AAH), using advanced humanized mouse models. These models mimic human liver conditions better than traditional mouse models, allowing researchers to explore cellular interactions and metabolic changes in the liver that contribute to disease. The lab aims to uncover how specific signaling interactions between liver cells and immune cells are involved in AAH to identify potential treatment targets.
Alcoholic Liver DiseaseAlcohol Associated HepatitisHumanized Mouse ModelsLiver MetabolismCell Signaling
Research Aims
3AIM 01Examine NPC derived WNT4 and WNT10B signaling in hepatocyte antioxidant defense and bile acid synthesis.
AIM 02Investigate the role of NPC derived WNT2 and WNT5A in alcohol-induced steatosis and mitochondrial dysfunction.
AIM 03Study the impact of monocyte/macrophage subsets on hepatocyte steatosis and cholestasis.
Skills the Lab Values
Mouse ModelsRNA SequencingCell CultureFlow CytometryIn Vivo Imaging
Output against the department
Publications1,513top 1% of dept.3rd of 486
this lab
most publishedleast published
Citations233ktop 1% of dept.1st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.