University of Arizona · PharmacologyOcular Viral Therapeutics Lab
Abhijit A Date · Tucson, Arizona
Research Focus
Dr. Abhijit A Date's lab at the University of Arizona focuses on developing more effective treatments for ocular herpes simplex virus infections, which are a major cause of blindness. The lab is particularly interested in repurposing an existing antiviral drug, adefovir dipivoxil, to create long-acting formulations that improve patient compliance. By using innovative strategies such as nanosuspensions, the lab aims to enhance how this medication is delivered to the eye, ensuring better outcomes for patients.
ocular herpesantiviral therapynanosuspensionspatient compliancedrug repurposing
Research Aims
5AIM 01Evaluate the effectiveness of adefovir dipivoxil compared to current treatments for ocular herpes.
AIM 02Develop hydrophobic salts of adefovir dipivoxil to improve drug delivery.
AIM 03Characterize and test new nanosuspensions of adefovir dipivoxil in preclinical models.
AIM 04Assess the safety and efficacy of new formulations in animal models.
AIM 05Enhance patient compliance with reduced dosing frequency of ocular medications.
Skills the Lab Values
cell culturein vivo efficacy testingocular pharmacokineticsnanoformulation developmentex-vivo permeability studies
Output against the department
Publications95bottom 23% of dept.353rd of 462
this lab
most publishedleast published
Citations6.4kbottom 45% of dept.252nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.