Cornell University · EngineeringAdipose Tissue and Cancer Mechanobiology Lab
Claudia Fischbach · Ithaca, New York
Research Focus
Dr. Claudia Fischbach's lab at Cornell University is focused on understanding how the mechanical properties of adipose tissue influence breast cancer, particularly in the context of obesity. The research investigates how changes in adipose tissue and fat cells affect tumor invasion and metastasis. By combining computational models, cell culture techniques, and analysis of human specimens, the lab aims to uncover new insights that could potentially improve patient outcomes in breast cancer.
breast canceradipose tissuetumor invasionobesityextracellular matrixmechanical propertieslipid metabolismsingle-cell analysistransgenic mouse models
Research Aims
3AIM 01Define the physical properties of white adipose tissue in the breast and their effect on tumor invasion.
AIM 02Determine how tumor-induced lipid loss affects adipose tissue properties and tumor cell metabolism.
AIM 03Establish the molecular basis of lipid loss in lean versus obese adipocytes and its impact on tumor invasion.
Skills the Lab Values
cell cultureRNA transcriptomicsbioinformaticscomputer modelingimmunohistochemistryflow cytometrymechanical testingmicroscopytransgenic mouse techniques
Output against the department
Publications180bottom 45% of dept.152nd of 278
this lab
most publishedleast published
Citations9.5ktop 37% of dept.104th of 278
this lab
most citedleast cited
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