Harvard University · BiologyThe Hemoglobin Dynamics Lab
Sichen Shao · Cambridge, Massachusetts
Research Focus
Dr. Sichen Shao's lab at Harvard Medical School focuses on understanding how red blood cells develop and function by studying a special enzyme called UBE2O. This enzyme helps to manage the proteins needed to form healthy red blood cells, which are essential for carrying oxygen throughout the body. By exploring the mechanisms behind protein quality control and degradation, the lab aims to uncover important factors related to blood disorders and potential new therapies.
red blood cellsprotein degradationube2ohemoglobinblood disorderscell differentiationubiquitin-proteasome systemproteomicsribosome clearance
Research Aims
3AIM 01Investigate how UBE2O mediates protein quality control during red blood cell differentiation.
AIM 02Identify mechanisms and factors that target substrates for degradation by UBE2O.
AIM 03Explore the role of UBE2O in ribosome clearance during red blood cell maturation.
Skills the Lab Values
proteomicscell culturebiochemical assaysCRISPRWestern blottingmouse modelsmass spectrometryprotein purificationenzyme assays
Output against the department
Publications71bottom 20% of dept.826th of 1,033
this lab
most publishedleast published
Citations4.9kbottom 37% of dept.647th of 1,033
this lab
most citedleast cited
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