The University of Texas at Austin · NeuroscienceT Cell Development and Tolerance Lab
Lauren Ilyse Richie Ehrlich · Austin, Texas
Research Focus
Dr. Lauren Ilyse Richie Ehrlich's lab studies how T cells develop in the thymus and learn to distinguish between harmful pathogens and the body's own cells to prevent autoimmune diseases. The team focuses on understanding the roles of specific receptors, CCR4 and CCR7, in promoting T cell tolerance to various self-antigens. This research has important implications for improving immune responses and preventing autoimmunity.
T cell developmentautoimmunitythymic toleranceCCR4CCR7self-antigensdendritic cellsregulatory T cellsimmune response
Research Aims
3AIM 01Investigate the role of CCR4 in mediating tolerance to inflammatory self-antigens.
AIM 02Examine how CCR7 influences tolerance to tissue-restricted self-antigens in the thymus.
AIM 03Assess the functional impact of CCR4 and CCR7 on autoimmunity in deficient mouse models.
Skills the Lab Values
T cell receptor sequencingcell culture techniquesflow cytometryimmunological assaysmouse modelsdata analysis using RWestern blottingRNA extraction and processinghistology techniques
Output against the department
Publications8bottom 2% of dept.659th of 671
this lab
most publishedleast published
Citations3bottom 1% of dept.665th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.