Harvard University · GeneticsManning Oncology Lab
Brendan D. Manning · Cambridge, Massachusetts
Research Focus
The Manning lab at Harvard focuses on understanding how certain signaling pathways in cells become malfunctioning in cancer, specifically the PI3K and mTOR pathways. They investigate the mechanisms behind tumor growth and how cancer cells adapt their metabolism to thrive. The lab uses innovative genetic mouse models and advanced methodologies to reveal new ways to target these cancer pathways, aiming to develop novel cancer therapies.
PI3KmTORcancer metabolismtumor microenvironmentgenetic mouse models
Research Aims
4AIM 01Investigate the biochemical mechanisms of the TSC complex in cancer.
AIM 02Explore how mTORC1 integrates oncogenic signals in the tumor microenvironment.
AIM 03Analyze metabolic changes due to PI3K-mTOR signaling in different tumors.
AIM 04Identify targetable vulnerabilities in tumors with aberrant mTOR regulation.
Skills the Lab Values
cell culturebiochemical assaysmouse modelsmolecular biology techniquesgene expression analysis
Output against the department
Publications224top 38% of dept.97th of 259
this lab
most publishedleast published
Citations42ktop 14% of dept.37th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.