University of California-Irvine · Microbiology & ImmunologyDNMT3A Mutations and Inflammation Lab
Minji Byun · Irvine, California
Research Focus
Dr. Minji Byun's lab at UC Irvine focuses on understanding how mutations in the DNMT3A gene, particularly common in older adults, affect inflammation and increase the risk for diseases like cancer and heart disease. The lab uses advanced human cell models to explore the molecular mechanisms linking these mutations to altered immune responses. Their goal is to uncover insights that could lead to new treatments for diseases associated with DNMT3A mutations.
DNMT3A mutationsinflammationhematologic cancerscardiovascular diseasehuman myeloid cellsepigeneticsstem cell researchcytokinesimmune responsesingle-cell transcriptomics
Research Aims
5AIM 01Investigate the impact of DNMT3A mutations on the inflammatory response of human macrophages.
AIM 02Characterize the epigenetic changes in myeloid cells associated with DNMT3A mutations.
AIM 03Examine the role of IL-6 in the inflammatory response of DNMT3A-mutated macrophages.
AIM 04Utilize single-cell transcriptomics to assess the inflammatory profiles of primary myeloid cells with DNMT3A mutations.
AIM 05Develop novel therapeutic strategies to treat pathologies related to DNMT3A mutations.
Skills the Lab Values
DNA methylation analysiscell culture techniqueshuman pluripotent stem cell differentiationmyeloid cell modelingmolecular profilingsingle-cell RNA sequencingbiobank data analysisimmunofluorescencecytokine assaygene expression analysis
Output against the department
Publications49bottom 11% of dept.433rd of 486
this lab
most publishedleast published
Citations2.6kbottom 16% of dept.409th of 486
this lab
most citedleast cited
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