Brown University · Microbiology & ImmunologyCaspase Immunity Lab
Amanda M Jamieson · Providence, Rhode Island
Research Focus
Dr. Amanda Jamieson's lab at Brown University researches how the immune system responds to severe respiratory infections like influenza and bacterial pneumonia. They focus on a specific protein called Caspase-8, which helps regulate cell death in immune cells called macrophages. By studying these processes, the lab aims to find ways to improve treatments for infections that cause high rates of illness and death.
Caspase-8macrophagesrespiratory infectionscell deathtoleranceinfluenzabacterial pneumoniainnate immunitydisease resistanceinfectious diseases
Research Aims
5AIM 01Investigate the role of Caspase-8 in lung macrophages during influenza and bacterial coinfection.
AIM 02Explore how regulated cell death affects resistance and tolerance during respiratory infections.
AIM 03Develop in vitro and in vivo models to study complex pulmonary infections.
AIM 04Establish the impact of macrophage cell death on host responses to infections.
AIM 05Identify potential new treatments for patients with severe lung infections.
Skills the Lab Values
PCRcell cultureflow cytometrymouse modelsWestern blotRNA sequencingin vitro assaysin vivo experimentsbiochemical assaysimmunohistochemistry
Output against the department
Publications220top 28% of dept.138th of 486
this lab
most publishedleast published
Citations11ktop 33% of dept.159th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.