Northwestern University · BiologyTransendothelial Migration and Inflammation Unit
William A Muller · Evanston, Illinois
Research Focus
Dr. William A. Muller's lab at Northwestern University focuses on understanding how white blood cells migrate across blood vessel walls during inflammation. By studying this process, known as transendothelial migration, the lab aims to discover new methods to modify inflammation therapeutically. The researchers have made significant advancements in identifying crucial molecules and mechanisms that facilitate this migration, which could lead to better treatment strategies for inflammatory diseases.
transendothelial migrationinflammationleukocytesendothelial cellsdisease progressionsignal pathwaysanti-inflammatory therapiespulmonary vascular bedmonocytesdendritic cells
Research Aims
5AIM 01Investigate the mechanisms that regulate transendothelial migration of leukocytes during inflammation.
AIM 02Identify key molecules involved in the signaling pathways that promote leukocyte migration.
AIM 03Develop therapeutic strategies to selectively block inappropriate inflammation.
AIM 04Study the role of transendothelial migration in various inflammatory disease models.
AIM 05Explore the differences in transendothelial migration in pulmonary versus systemic circulation.
Skills the Lab Values
cell culturein vivo modelsbiochemical assaysgenetic manipulationmicroscopyflow cytometryWestern blotrecombinant DNA techniquesimmunohistochemistry
Output against the department
Publications553top 6% of dept.63rd of 1,033
this lab
most publishedleast published
Citations21ktop 19% of dept.192nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.