Stanford University · BiologyGentles Tumor Lab
Andrew J. Gentles · Stanford, California
Research Focus
Dr. Andrew Gentles' lab studies the complex ecosystems of tumors to understand how they affect treatment responses, particularly in rare cancers like clear cell ovarian and renal cancers. The team uses advanced techniques like single-cell RNA sequencing and imaging to identify specific cell types and their roles in disease progression and treatment outcomes. This research aims to enhance prognostic methods and improve therapeutic strategies for patients.
tumor ecosystemsimmunotherapyclear cell cancersingle-cell RNA sequencingtumor microenvironment
Research Aims
5AIM 01Identify cancer-specific cell transcriptional states associated with survival.
AIM 02Characterize the spatial organization of cells within tumors using advanced imaging.
AIM 03Integrate single-cell and bulk data to uncover mechanisms of therapy response.
AIM 04Validate cancer-specific findings using tissue microarrays.
AIM 05Explore common mechanisms between clear cell cancers for improved treatment strategies.
Skills the Lab Values
single cell RNA sequencing (scRNA-seq)bulk RNA sequencingtissue microarray analysisCODEX imagingdata integration
Output against the department
Publications305top 18% of dept.188th of 1,033
this lab
most publishedleast published
Citations46ktop 6% of dept.60th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.