University of Maryland, Baltimore · Biomedical EngineeringHIV Treatment Innovation Lab
Linda Chang · Baltimore, Maryland
Research Focus
Dr. Linda Chang's lab at the University of Maryland Baltimore focuses on developing innovative treatment strategies for HIV, especially in patients with substance use disorders. The lab explores the use of MR-guided focused ultrasound technology to temporarily open the blood-brain barrier, allowing targeted delivery of HIV treatments like antiretroviral therapy and CRISPR gene editing. The ultimate goal is to eliminate HIV reservoirs in the brain and improve outcomes for those affected by HIV-associated cognitive disorders.
HIVfocused ultrasoundblood-brain barrierCRISPRneurogenesisneurocognitive disorderssubstance use disordersviral reservoirsgene therapyantiretroviral therapy
Research Aims
5AIM 01Utilize MR-guided focused ultrasound to open the blood-brain barrier in HIV patients.
AIM 02Deliver long-acting antiretroviral therapy effectively into the central nervous system.
AIM 03Eliminate HIV proviral DNA using CRISPR technology in rodent models.
AIM 04Investigate neurogenesis and microglial activation following focused ultrasound treatment.
AIM 05Explore low-intensity focused ultrasound for addiction treatment in rodent models.
Skills the Lab Values
MR-guided focused ultrasoundCRISPR/Cas9rodent modelsdrug delivery techniquescell cultureimmunohistochemistrymolecular biology techniquesbehavioral assaysbiostatisticsneuroimaging
Output against the department
Publications206bottom 48% of dept.311th of 595
this lab
most publishedleast published
Citations13ktop 27% of dept.158th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.