Loyola University Chicago · PhysiologyKirk Cardiology Lab
Jonathan A Kirk · Chicago, Illinois
Research Focus
Dr. Jonathan A. Kirk's lab focuses on understanding the mechanics of heart diseases, particularly how misfolded proteins affect heart function. They aim to improve our knowledge of protein quality control in heart muscle cells, which could lead to new treatments for heart failure. The lab utilizes advanced techniques to visualize how these protein issues arise in healthy and diseased hearts.
heart failureprotein quality controlsarcomerecardiomyopathyBAG3 gene therapy
Research Aims
3AIM 01Explore how protein quality control operates in heart muscle cells.
AIM 02Identify the effects of misfolded proteins on heart function.
AIM 03Investigate the regulation of key protein levels in heart disease.
Skills the Lab Values
live cell imagingX-ray diffractionbiophysical assaystransgenic micemass spectrometrymechanical stress testingcell culturegenetic manipulationdata analysis
Output against the department
Publications172top 41% of dept.116th of 286
this lab
most publishedleast published
Citations3.1kbottom 25% of dept.214th of 286
this lab
most citedleast cited
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