University of North Carolina at Chapel Hill · Microbiology & ImmunologyT Cell Immunobiology Lab
John Justin Milner · Chapel Hill, North Carolina
Research Focus
Dr. John Milner's lab explores how specific proteins influence T cell behavior during chronic infections like HIV and hepatitis. His research focuses on understanding how epigenetic regulators can modify T cells, which could potentially lead to new treatments that restore their effectiveness. By studying the roles of certain proteins in T cell function, the lab aims to uncover strategies to combat immune dysfunction in persistent infections.
T cell differentiationepigenetic regulationT cell exhaustionchronic infectionBET inhibitorsimmune responsecancer immunotherapy
Research Aims
3AIM 01Determine the role of BRD4 in controlling the differentiation and stability of exhausted CD8 T cells during chronic infection.
AIM 02Define BRD4's role in regulating exhaustion-specific enhancer elements in CD8 T cells.
AIM 03Assess BRD2 and BRD3 as regulators of T cell exhaustion and investigate the effects of BET inhibitors on CD8 T cell differentiation.
Skills the Lab Values
genetic mouse modelsin vivo imagingflow cytometrycell cultureRNA sequencingchromatin immunoprecipitation (ChIP)PCRwestern blottingdata analysis in R
Output against the department
Publications1bottom 1% of dept.482nd of 486
this lab
most publishedleast published
Citations0bottom 1% of dept.482nd of 486
this lab
most citedleast cited
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