Stanford University · BiologyMast Cell Allergy Research Lab
Stephen Joseph Galli · Stanford, California
Research Focus
Dr. Stephen Joseph Galli's lab at Stanford University studies how genetic variations affect the immune responses of mast cells to honeybee venom. They aim to uncover how these immune responses can be both harmful, leading to allergic reactions, or beneficial, potentially offering protection against venom toxicity. Their research involves using genetically diverse mice to explore these pathways and identify ways to improve treatment for venom allergies and related disorders.
mast cellsallergyhoneybee venomgenetic variationIgEimmune responseanaphylaxistoxicologyCollaborative Cross micevenom toxicity
Research Aims
5AIM 01Identify genetic traits that influence mast cell responses to honeybee venom
AIM 02Screen Collaborative Cross mice for susceptibility to honeybee venom toxicity
AIM 03Map genetic loci associated with mast cell-dependent susceptibility vs. resistance to venom
AIM 04Confirm regulatory factors involved in mast cell functions using QTL analysis
AIM 05Investigate the dual role of mast cells in allergic reactions and protective immunity against venoms.
Skills the Lab Values
mouse modelsQTL mappingcell cultureimmunohistochemistryPCRflow cytometrycytokine assaysgenetic screeningdata analysissurvival analysis
Output against the department
Publications562top 6% of dept.57th of 1,033
this lab
most publishedleast published
Citations62ktop 3% of dept.30th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.