University of Miami · GeneticsThe Gene Boundaries Lab
Danny Reinberg · Coral Gables, Florida
Research Focus
Dr. Danny Reinberg's lab at the University of Miami focuses on understanding how proteins regulate the spatial organization of genes within the genome during cell differentiation. By studying how certain proteins, like CTCF and MAZ, create boundaries that separate repressed from active gene regions, the lab aims to reveal insights about gene expression and cell type identity. Their research has implications for understanding development and diseases related to gene regulation.
chromatin interactionsgene expressioncell differentiationCTCFMAZHox genesinsulation factorsgenetic manipulationRNA binding
Research Aims
5AIM 01Investigate how CTCF and MAZ contribute to chromatin boundary formation.
AIM 02Explore the role of RNA in regulating chromatin interactions.
AIM 03Characterize genetic manipulation effects on Hox gene expression.
AIM 04Identify new insulating proteins involved in gene regulation.
AIM 05Examine the mechanisms of chromatin loop formation during cell differentiation.
Skills the Lab Values
molecular cloningCRISPRRNA sequencingin vivo genetic manipulationcell culturechromatin immunoprecipitationWestern blottingmicroscopygenomic editing
Output against the department
Publications387top 19% of dept.50th of 259
this lab
most publishedleast published
Citations78ktop 8% of dept.20th of 259
this lab
most citedleast cited
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