Columbia University in the City of New York · NeuroscienceAlzheimer's Genetic Research Lab
Gao Wang · New York, New York
Research Focus
Dr. Gao Wang's lab focuses on understanding the genetic and molecular basis of Alzheimer's Disease (AD) by using advanced computational methods and multi-omics data. They study how genetic variations affect RNA modifications and other molecular traits in brain cells, particularly in diverse populations such as African Americans and Hispanics. The ultimate goal is to identify specific genes and processes that contribute to AD, which may pave the way for new therapeutic strategies.
Alzheimer's Diseasegenetic mappingmulti-omicsRNA modificationsepigeneticscausal variantsneuroinflammationtherapeutic developmentAI in genomics
Research Aims
5AIM 01Identify causal genes and cell types involved in Alzheimer's Disease.
AIM 02Integrate multi-omics data to elucidate genetic variants and patient diversity in AD.
AIM 03Map RNA modifications and their genetic regulators in aging brains.
AIM 04Develop advanced computational methods for multi-omics analysis.
AIM 05Investigate molecular mechanisms of identified targets using human iPSCs.
Skills the Lab Values
RNA sequencinggenetic analysismulti-omics integrationdata analysis using Rcomputational biologybioinformaticscell culturestatistical modelingmachine learning
Output against the department
Publications185top 40% of dept.267th of 671
this lab
most publishedleast published
Citations16ktop 25% of dept.170th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.