Purdue University-Main Campus · PharmacologyGene Regulation and Therapeutics Lab
Danzhou Yang · West Lafayette, Indiana
Research Focus
Dr. Danzhou Yang's lab at Purdue University focuses on developing innovative therapies for cancer and inflammatory diseases. The lab investigates the regulation of gene expression, specifically targeting a unique structure in DNA known as a G-quadruplex to suppress the overexpression of a protein called PDGFR-beta, which is implicated in various diseases. By designing and synthesizing small molecular compounds that interact with this structure, the lab aims to create more effective treatments for conditions where PDGFR-beta is a key player.
PDGFR-betaG-quadruplexgene expressioncancer therapyberberine
Research Aims
3AIM 01Characterize the structure of berberine-guanine conjugates with PDGFR-beta vG4.
AIM 02Design and synthesize specific berberine-guanine conjugates for gene suppression.
AIM 03Evaluate the effects of berberine-guanine conjugates on PDGFR-beta in cancer cells.
Skills the Lab Values
DNA structure analysisNuclear Magnetic Resonance (NMR)synthesis of small moleculescell culturegene expression assays
Output against the department
Publications168bottom 46% of dept.248th of 462
this lab
most publishedleast published
Citations14ktop 27% of dept.127th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.