University of Florida · GeneticsMartins Gene Therapy Lab
Mauricio A Martins · Gainesville, Florida
Research Focus
Dr. Mauricio A Martins' lab at the University of Florida is focused on developing innovative gene therapies using adeno-associated viruses (AAV) to fight HIV. The team works to improve how these therapies can be safely administered to individuals with prior immunity to AAV, tackling a major obstacle in HIV treatment. They aim to create long-lasting immunity in infants to prevent pediatric HIV infections, especially in high-risk regions.
Adeno-associated virusHIV immunotherapybroadly neutralizing antibodiesgene therapypediatric HIV prevention
Research Aims
4AIM 01Identify the least prevalent muscle-tropic AAV capsid in sub-Saharan Africa to enable treatment for HIV+ individuals.
AIM 02Assess the depletion of serum IgG antibodies and its effects on neutralizing antibodies against AAV.
AIM 03Test if depleting pre-existing neutralizing antibodies enhances AAV-mediated delivery of HIV therapeutic agents.
AIM 04Extend the window for effective AAV therapy in infants by exploring prenatal tolerance mechanisms.
Skills the Lab Values
AAV vector designimmunological assaystransgene deliverycell culture techniquesanimal models (rhesus macaques)
Output against the department
Publications57bottom 10% of dept.231st of 259
this lab
most publishedleast published
Citations1.2kbottom 5% of dept.245th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.