University of Southern California · Microbiology & ImmunologyEoh Antibiotics Lab
Hyungjin Eoh · Los Angeles, California
Research Focus
Dr. Hyungjin Eoh's lab focuses on understanding how Mycobacterium tuberculosis, the bacteria that causes tuberculosis (TB), develops resistance to antibiotics, particularly in drug-resistant forms of the disease. By investigating the metabolism of trehalose in these bacteria, the lab aims to uncover mechanisms that allow M. tuberculosis to survive antibiotic treatments, which is crucial for developing new therapies. The insights gained from this research could lead to more effective treatments for patients with drug-resistant TB, improving public health outcomes worldwide.
drug resistancetuberculosistrehalose metabolismpersister cellsantibiotic toleranceM. tuberculosispathogenesisdrug development
Research Aims
4AIM 01Investigate the role of trehalose metabolism in the development of drug resistance in M. tuberculosis.
AIM 02Examine the hypervirulence of specific TB strains associated with drug-resistant tuberculosis.
AIM 03Determine the metabolic adaptations of M. tuberculosis persister cells during antibiotic treatment.
AIM 04Develop new therapeutic interventions for drug-resistant tuberculosis patients.
Skills the Lab Values
cell cultureCRISPR interferencequantitative PCRflow cytometryin vivo murine modelsmetabolomicsbacterial geneticsmouse modelsex vivo studies
Output against the department
Publications63bottom 17% of dept.403rd of 486
this lab
most publishedleast published
Citations2.8kbottom 19% of dept.393rd of 486
this lab
most citedleast cited
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