University of Southern California · PharmacologyLu Splicing Lab
Zhipeng Lu · Los Angeles, California
Research Focus
Dr. Zhipeng Lu's lab at the University of Southern California focuses on understanding how alternative splicing works and its implications for health and disease. They develop innovative methods to analyze RNA structures and their interactions with proteins, aiming to decode how these processes contribute to diseases like cancer and neurological disorders. The lab's work is particularly relevant for advancing precision medicine by targeting splicing mechanisms for therapeutic purposes.
alternative splicingRNA structureRNA-protein interactionsCRISPRneurodegenerationtherapeutic targetingtranscriptomecell differentiation
Research Aims
3AIM 01Develop a high throughput technology to capture RNA structures and interactions
AIM 02Analyze RNA structures in chromatin-associated RNAs
AIM 03Test how mutations affect RNA structures and splicing regulation
Skills the Lab Values
RNA sequencingCRISPR genome editingchemical crosslink-ligationcell culturebiochemical assaysdata analysisRNA structure modelingmouse modelsmolecular cloning
Output against the department
Publications53bottom 8% of dept.426th of 462
this lab
most publishedleast published
Citations2.8kbottom 20% of dept.368th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.