Case Western Reserve University · BiologyRamakrishnan Lab
Parameswaran Ramakrishnan · Cleveland, Ohio
Research Focus
Dr. Parameswaran Ramakrishnan's lab focuses on understanding the role of a protein called Sam68 in inflammatory bowel disease, particularly ulcerative colitis. The lab investigates how Sam68 signaling affects immune responses in the intestinal epithelial cells, aiming to identify new therapeutic approaches to treat this chronic condition. By exploring both human and mouse models, including advanced techniques such as organoids, the research seeks to uncover mechanisms that contribute to inflammation and potential treatment targets.
ulcerative colitisinflammatory bowel diseaseSam68proinflammatory signalingintestinal epithelial cells
Research Aims
3AIM 01Identify the molecular mechanisms of Sam68 signaling in inflammatory responses.
AIM 02Investigate the in vivo roles of Sam68 in intestinal epithelial cells during inflammation.
AIM 03Characterize the proinflammatory role of Sam68 in patients with ulcerative colitis.
Skills the Lab Values
cell culture3D organoid modelsmouse modelsWestern blotCRISPRcoculture techniquesRNA sequencingmolecular signaling pathways
Output against the department
Publications83bottom 26% of dept.766th of 1,033
this lab
most publishedleast published
Citations2.6kbottom 18% of dept.842nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.