The University of Texas Medical Branch at Galveston · Microbiology & ImmunologyThe Latency Lab
Haitao Hu · Galveston, Texas
Research Focus
Dr. Haitao Hu's lab at the University of Texas Medical Branch focuses on researching new strategies to fight HIV by targeting specific cellular proteins that regulate the virus's ability to remain dormant in the body. Their work involves using small molecules to modulate these proteins and enforce HIV latency, which could lead to innovative treatments for HIV infections. The lab employs a mix of molecular and cell biology techniques to explore these interactions and develop potential therapeutic solutions.
HIVepigenetic regulationBRD4latent infectionsmall molecules
Research Aims
3AIM 01Investigate if BRD4 is a target for the small molecules ZL0580 and YL0255.
AIM 02Elucidate the mechanisms by which these molecules induce HIV suppression.
AIM 03Test the efficacy of these compounds to repress latent HIV in vivo.
Skills the Lab Values
cell cultureanimal modelsmolecular dockingprotein-protein interaction assaystranscription analysis
Output against the department
Publications333top 14% of dept.66th of 486
this lab
most publishedleast published
Citations4.0kbottom 30% of dept.340th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.