Wright State University-Main Campus · PhysiologyElbasiouny Neurophysiology Lab
Sherif M Elbasiouny · Dayton, Ohio
Research Focus
Dr. Sherif M Elbasiouny's research focuses on understanding the excitability of motoneurons, which are critical to muscle movement and are affected in conditions like amyotrophic lateral sclerosis (ALS). His lab investigates how changes in the electrical properties of these neurons contribute to their death in ALS and frontotemporal dementia (FTD). By using various mouse models, the lab aims to identify ion channel mechanisms that might serve as new targets for effective treatments.
ALSmotoneuron excitabilityion channelsTDP43frontotemporal dementia
Research Aims
3AIM 01Determine the form of motoneuronal excitability dysregulation at symptom onset.
AIM 02Identify the cellular mechanisms mediating MN hypo-excitability via computational modeling.
AIM 03Empirically verify model predictions of reduced Kv2.1 channel activation in MNs and cortical neurons.
Skills the Lab Values
electrophysiologymouse modelsimmunohistochemistryWestern blotcomputational modeling
Output against the department
Publications56bottom 9% of dept.260th of 286
this lab
most publishedleast published
Citations1.3kbottom 4% of dept.274th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.