University of Alabama at Birmingham · BiologyThe Vascular Epigenetics Lab
Ming He · Birmingham, Alabama
Research Focus
Dr. Ming He's lab at the University of Alabama at Birmingham focuses on how certain modifications to histone proteins in endothelial cells (the cells lining blood vessels) contribute to cardiovascular diseases, particularly under conditions of diabetes and abnormal blood flow. By exploring these novel histone modifications, the lab aims to uncover mechanisms that lead to endothelial dysfunction and accelerated atherosclerosis. The research combines cell culture techniques with mouse models to investigate the impacts of these modifications on health and disease.
histone modificationendothelial cellsdiabetesatherosclerosisepigeneticsvascular healthchromatin accessibilityshear stress
Research Aims
3AIM 01Investigate the effect of O-GlcNAc modification on endothelial cell function under diabetic conditions.
AIM 02Define the epigenetic features of histone modifications in endothelial cells affected by shear stress.
AIM 03Evaluate the impact of histone modifications on the development of atherosclerosis in mouse models.
Skills the Lab Values
cell cultureChIP-seqRNA sequencingmouse modelsflow cytometrygenome mappingmass spectrometrydata integration techniquesfunctional assays
Output against the department
Publications102bottom 35% of dept.663rd of 1,033
this lab
most publishedleast published
Citations1.7kbottom 11% of dept.918th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.