University of California-Merced · EngineeringVascular Regeneration Lab
Joel A. Spencer · Merced, California
Research Focus
Dr. Joel A. Spencer's research lab focuses on understanding how the vascular system and endothelial cells contribute to the regeneration of the thymus after chemotherapy. By using advanced imaging techniques, the lab aims to reveal how these blood vessels behave after treatment, which can impact the recovery of the immune system. The work has implications for improving therapies for blood cancers and enhancing immune function post-treatment.
thymus regenerationendothelial cellsintravital imaginghematopoietic cell transplantationcytotoxic therapy
Research Aims
3AIM 01Utilize high-resolution intravital imaging to observe thymic vascular physiology in real-time.
AIM 02Define endothelial cell heterogeneity using flow cytometry and RNA sequencing.
AIM 03Characterize thymus microenvironmental changes after cytotoxic conditioning with advanced imaging techniques.
Skills the Lab Values
intravital imagingtwo-photon microscopyflow cytometrysingle cell RNA sequencingimmunostaining
Output against the department
Publications76bottom 14% of dept.239th of 278
this lab
most publishedleast published
Citations8.4ktop 45% of dept.125th of 278
this lab
most citedleast cited
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