Johns Hopkins University · Microbiology & ImmunologyPekosz Virology Lab
Andrew S. Pekosz · Baltimore, Maryland
Research Focus
Dr. Andrew S. Pekosz's lab studies the measles virus, particularly focusing on how the measles vaccine works and its effects on the immune system. The research involves understanding the differences between the wild type measles virus and the vaccine-strain virus in terms of how they replicate and stimulate immune responses. This work is vital for improving vaccination strategies and understanding the long-term health impacts of measles infection and vaccination.
measles virusvaccinationimmune responseattenuated vaccinesviral replicationantibody diversitynon-human primatesimmune stimulation
Research Aims
4AIM 01Identify viral determinants of inefficient replication of the vaccine strain measles virus in immune cells.
AIM 02Investigate in vivo replication sites and RNA clearance dynamics of the vaccine strain compared to wild type measles virus in rhesus macaques.
AIM 03Define immune responses to infection with the vaccine strain and wild type measles virus.
AIM 04Determine mechanisms by which wild type measles virus infection decreases antibody diversity.
Skills the Lab Values
PCRflow cytometryin situ hybridizationimmunohistochemistryantibody titer measurementanimal modelsRNA sequencingcell cultureviral assaysdata analysis using Python
Output against the department
Publications440top 7% of dept.33rd of 486
this lab
most publishedleast published
Citations18ktop 21% of dept.102nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.