Johns Hopkins University · PhysiologyWong Lab
Guang William Wong · Baltimore, Maryland
Research Focus
Dr. Guang William Wong's lab at Johns Hopkins University focuses on understanding how certain hormones impact liver fat metabolism. They study CTRP1, a hormone that helps regulate fat storage and utilization in the liver and adipose tissue. By using mouse models to investigate the mechanisms behind CTRP1's action, the lab aims to uncover new strategies to combat diseases like non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
CTRP1hepatic lipid metabolismnon-alcoholic fatty liver diseaseadipose tissuehormonal regulation
Research Aims
2AIM 01Characterize the role of CTRP1 in hepatic lipid metabolism.
AIM 02Investigate the protective mechanisms of CTRP1 against fatty liver inflammation and fibrosis associated with NASH.
Skills the Lab Values
mouse modelsgenetic knockout techniquesadipocyte culturemetabolic assayshistological analysisprotein quantification techniquesgene expression analysisWestern blotspectrophotometrydata analysis using R
Output against the department
Publications215top 30% of dept.85th of 286
this lab
most publishedleast published
Citations16ktop 19% of dept.54th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.