University of California-San Diego · PharmacologyNeurodegenerative Disease Therapeutics Lab
Conor Caffrey · La Jolla, California
Research Focus
Dr. Conor Caffrey's lab at UC San Diego focuses on developing new treatments for neurodegenerative diseases, specifically tauopathies like Alzheimer's disease. The lab investigates microtubule-stabilizing compounds to enhance brain health and prevent cognitive decline. Their research includes testing a new compound, CNDR-51997, which has shown promise in improving neuronal function and stability in preclinical models.
Alzheimer's diseasetauopathiesmicrotubule stabilizationtriazolopyrimidinesdrug developmentneurodegenerationpharmacokineticscognitive performance
Research Aims
4AIM 01To develop new microtubule-stabilizing agents as treatments for Alzheimer's disease.
AIM 02To evaluate the pharmacokinetics and safety of candidate drugs in preclinical models.
AIM 03To identify and characterize novel compounds that enhance microtubule stability in neurons.
AIM 04To submit an investigational new drug application for promising compounds developed in the lab.
Skills the Lab Values
animal modelingdrug formulationin vitro testingstructure-activity relationship analysiscognitive behavioral assessmentoral bioavailability studiesorganotypic brain slice culturespharmacological profiling
Output against the department
Publications189top 47% of dept.217th of 462
this lab
most publishedleast published
Citations8.7ktop 43% of dept.198th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.