University of Texas Southwestern Medical Center · GeneticsWntless Development Lab
Xiaochun Li · Dallas, Texas
Research Focus
Dr. Xiaochun Li's lab focuses on understanding the molecular mechanisms involved in Zaki Syndrome, a genetic disorder that leads to severe developmental issues in children. By studying the Wntless (WLS) protein and its role in Wnt signaling, the lab seeks to uncover how genetic mutations disrupt normal development. This research aims not only to deepen our understanding of human developmental biology but also to explore potential therapeutic strategies to treat conditions associated with birth defects.
Zaki SyndromeWnt signalingWntless (WLS)embryonic developmentdevelopmental abnormalities
Research Aims
5AIM 01Investigate how mutations in the WLS gene impact Wnt protein secretion.
AIM 02Elucidate the role of phospholipids in Wnt release from WLS.
AIM 03Identify novel binding partners of WLS and their roles in trafficking.
AIM 04Assess the impact of specific WLS mutations on developmental processes.
AIM 05Develop therapeutic strategies to target WLS for improved child health.
Skills the Lab Values
gene editingmolecular cloningcell culturetransfection techniquesbiochemical assaysCryoelectron Microscopyimmunoprecipitationanimal modelslivestock regeneration techniques
Output against the department
Publications363top 22% of dept.57th of 259
this lab
most publishedleast published
Citations7.3kbottom 39% of dept.158th of 259
this lab
most citedleast cited
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