University of Alabama at Birmingham · BiologyYoder Lab
Bradley K. Yoder · Birmingham, Alabama
Research Focus
Dr. Bradley K. Yoder's research lab focuses on understanding the role of cilia and their associated proteins in kidney health and disease. Their work investigates how mutations in certain genes cause kidney cysts and how these cysts are influenced by injury and cellular repair processes. By using mouse models, the lab aims to uncover the mechanisms behind cyst formation and identify potential therapeutic strategies to better manage polycystic kidney disease (PKD).
ciliopathyrenal cystsinjury responseciliogenesiscell cycle regulationp21PKD1PKD2cellular repair mechanismskidney disease
Research Aims
5AIM 01Investigate the role of CDKN1A (p21) in cyst development and severity in mutant mice.
AIM 02Examine how ciliary dysfunction affects kidney injury and repair responses.
AIM 03Define the molecular mechanisms underlying injury-induced cyst formation.
AIM 04Determine the impact of renal injury on epithelial cell behavior in cystic disease models.
AIM 05Identify intercellular signaling pathways dysregulated in cilia-associated kidney diseases.
Skills the Lab Values
mouse modelsgene expression analysisimmunohistochemistrylineage tracingPCRWestern blottingRNA sequencingcell culturein vitro assaysbiochemical assays
Output against the department
Publications207top 32% of dept.327th of 1,033
this lab
most publishedleast published
Citations17ktop 24% of dept.245th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.